Liverpool (5/2 Premier League outright) played their final game in hand in midweek, beating Leeds United 6-0 at Anfield, and they are now just three points behind City (3/10).
The two title challengers will go head-to-head in April, but for now, Guardiola’s men have a job to do as they look to bounce back from last Saturday’s 3-2 defeat to Tottenham.
Much of the talk ahead of kick-off has focused on Liverpool’s recent run, but Guardiola says his side cannot afford to focus on anyone but themselves.
He told reporters: “We know it’s a long road. We try to be ourselves every single game. Not just in the Premier League, in all competitions, and it’s nice to be there,” said the Spaniard.
“I am more than delighted to be in the position we are. We try to defend and attack better and try to win games. The Premier League is so tough, and we know it.”
City have been boosted by the news that both Jack Grealish and Gabriel Jesus are fit after injury, but Cole Palmer and Zack Steffen remain absent.
Everton (4/1 to be relegated) boss Frank Lampard will welcome back Abdoulaye Doucoure and Demarai Gray into this squad, but the game comes too soon for defensive duo Ben Godfrey and Yerry Mina.
Lampard concedes it will take time for his players to adapt to his methods, and he says Saturday’s challenge does not get any bigger.
He said: “Every time you go up against [Guardiola], you feel a very complete team,” Lampard said.
“It’s not only the in-game feeling but when you prepare, and you see them.
“Their winning record is incredible this season; even when they lose it doesn’t generally look like a normal loss. I’m taking them at face value; we have to be very organised and aggressive – and take our opportunities to do positive things in the game.”